The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis

S Tognin; A Richter; MJ Kempton; G Modinos; M Antoniades; M Azis; P Allen; MG Bossong; J Perez; C Pantelis; B Nelson; P Amminger; A Riecher-Rössler; N Barrantes-Vidal; MO Krebs; B Glenthøj; S Ruhrmann; G Sachs; BPF Rutten; L De Haan; M Van Der Gaag; P Mcguire; LR Valmaggia; M Calem; S Pisani; E Velthorst; TC Kraan; DS Van Dam; N Burger; P Mcgorry; A Politis; J Goodall; S Borgwardt; E Studerus; R Bressan; A Gadelha; E Brietzke; G Asevedo; E Asevedo; A Zugman; T Domínguez-Martínez; A Racciopi; TR Kwapil; M Monsonet; L Hinojosa; M Kazes; C Daban; J Bourgin; O Gay; C Mam-Lam-Fook; D Nordholm; L Randers; K Krakauer; L Glenthøj; M Nordentoft; D Gebhard; J Arnhold; J Klosterkötter; I Lasser; B Winklbaur; H Aschauer; PA Delespaul; J Van Os; P Mcguire

Journal article

The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis

S Tognin, A Richter, MJ Kempton, G Modinos, M Antoniades, M Azis, P Allen, MG Bossong, J Perez, C Pantelis, B Nelson, P Amminger, A Riecher-Rössler, N Barrantes-Vidal, MO Krebs, B Glenthøj, S Ruhrmann, G Sachs, BPF Rutten, L De Haan Show all

Schizophrenia Bulletin Open | Oxford University Press (OUP) | Published : 2022

DOI: 10.1093/schizbullopen/sgac040

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Abstract

Objective: To examine the association between baseline alterations in grey matter volume (GMV) and clinical and functional outcomes in people at clinical high risk (CHR) for psychosis. Methods: 265 CHR individuals and 92 healthy controls were recruited as part of a prospective multi-center study. After a baseline assessment using magnetic resonance imaging (MRI), participants were followed for at least two years to determine clinical and functional outcomes, including transition to psychosis (according to the Comprehensive Assessment of an At Risk Mental State, CAARMS), level of functioning (according to the Global Assessment of Functioning), and symptomatic remission (according to the CAARM..

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